autonomous drug-encapsulated nanoparticles: towards a novel non-invasive approach to prevent atherosclerosis

نویسندگان

alireza rowhanimanesh department of electrical engineering, center of excellence on soft computing and intelligent information processing (sciip), ferdowsi university of mashhad, mashhad, iran.

چکیده

introduction this paper proposes the concept of autonomous drug-encapsulated nanoparticle (adenp) as a novel non-invasive approach to prevent atherosclerosis. adenp consists of three simple units of sensor, controller (computing), and actuator. the hardware complexity of adenp is much lower than most of the nanorobots, while the performance is maintained by the synergism in the swarm architecture. materials and methods since high accumulation of low density lipoprotein (ldl) macromolecules within the arterial wall plays a critical role in the initiation and development of atherosclerotic plaques, the task of the swarm of adenps is autonomous feedback control of ldl level in the interior of the arterial wall. in this study, we consider two specific types of adenps with distinguishing capabilities. the performance of each type is evaluated and compared on a well-known mathematical model of the arterial wall through computer simulation. results simulation results demonstrate that the proposed approach can successfully reduce the ldl level to a desired value in the arterial wall of a patient with very high ldl level that is corresponding to the highest rates of cardiovascular disease events. moreover, it is shown that adenp is capable of distinguishing between healthy and unhealthy arterial walls to reduce the drug side effects. conclusion the proposed approach is a promising autonomous non-invasive method to prevent and treat complex diseases such as atherosclerosis.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Autonomous Drug-Encapsulated Nanoparticles: Towards a Novel Non-Invasive Approach to Prevent Atherosclerosis

Introduction This paper proposes the concept of autonomous drug-encapsulated nanoparticle (ADENP) as a novel non-invasive approach to prevent atherosclerosis. ADENP consists of three simple units of sensor, controller (computing), and actuator. The hardware complexity of ADENP is much lower than most of the nanorobots, while the performance is maintained by the synergism in the swarm architectu...

متن کامل

non-corrective approach to pronunciation

the aim of this study has been to find answers for the following questions: 1. what is the effect of immediate correction on students pronunciation errors? 2. what would be the effect of teaching the more rgular patterns of english pronunciation? 3. is there any significant difference between the two methods of dealing with pronuciation errore, i. e., correction and the teaching of the regular ...

15 صفحه اول

Remote Ischemic Conditioning: A Novel Non-Invasive Approach to Prevent Post-Stroke Depression

Post-stroke depression (PSD) is a common neuropsychiatric complication of stroke. However, due to the high expense and side effects of pharmacotherapy and the difficult-to-achieve of psychotherapy, the prevention and treatment of PSD are still far from satisfaction. Inflammation hypothesis is now playing an essential role in the pathophysiological mechanism of PSD, and it may be a new preventiv...

متن کامل

a novel approach to minimally invasive management of sigmoid volvulus

resection is the most common treatment choice for sigmoid volvulus, a common complication in our region. a new minimally invasive technique for sigmoid resection with local anesthesia was done in this study. this method is invented to avoid general on regional anesthesia in high-risk patients. nineteen patients were evaluated and then 14 were enrolled in this study. sigmoidectomy with a left lo...

متن کامل

Peptide Encapsulated Nanoparticles for Brain Drug Delivery

BBB is acting as a highly selective membrane that separates the circulating blood from brain fluid [1]. This barrier is formed by endothelial cells which are connected to each other at “tight” junctions that create a complete seal between them. Consequently, only lipophilic molecules are able to cross the barrier. Hydrophilic substances, in contrast, are unable to cross the lipid walls unless a...

متن کامل

Liposomal Encapsulated Rhodomyrtone: A Novel Antiacne Drug

Rhodomyrtone isolated from the leaves of Rhodomyrtus tomentosa possesses antibacterial, anti-inflammatory, and anti-oxidant activities. Since rhodomyrtone is insoluble in water, it is rather difficult to get to the target sites in human body. Liposome exhibited ability to entrap both hydrophilic and hydrophobic compounds and easily penetrate to the target site. The present study aimed to develo...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical physics

جلد ۱۰، شماره ۲، صفحات ۱۱۸-۱۳۲

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023